To set up and manage Google Workspace security settings, follow these steps:

1. Sign in to your Google Workspace admin console.
2. Go to the "Security" section.
3. Here, you can configure various security settings such as two-factor authentication, password policies, and device management.
4. To configure two-factor authentication, go to the "Advanced security" section and click on "Set up" next to "2-Step Verification." You can then require users to use a second factor when signing in, such as a phone or security key.
5. To configure password policies, go to the "Password" section and set requirements for password length, complexity, and expiration.
6. To manage device management settings, go to the "Devices" section and set requirements for device management, such as requiring users to use a passcode or encrypt their device.
7. You can also configure settings for phishing and malware protection, access control, and API security.
8. Once you have configured the desired security settings, click "Save" to apply them to your Google Workspace organization.

Note that some security settings may not be available on all Google Workspace plans. Additionally, it's important to regularly review and update your security settings to ensure the ongoing protection of your organization's data.